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KMID : 0043320230460060449
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Archives of Pharmacal Research
2023 Volume.46 No. 6 p.449 ~ p.499
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Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure?activity relationship, and biosynthesis
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Peng Jiang
Xiujuan Fu
Hong Niu
Siwei Chen
Feifei Liu
Yu Luo
Dan Zhang
Hui Lei
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Abstract
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Strains of the fungal genus Pestalotiopsis are reported as large promising sources of structurally varied biologically active metabolites. Many bioactive secondary metabolites with diverse structural features have been derived from Pestalotiopsis. Moreover, some of these compounds can potentially be developed into lead compounds. Herein, we have systematically reviewed the chemical constituents and bioactivities of the fungal genus Pestalotiopsis, covering a period ranging from January 2016 to December 2022. As many as 307 compounds, including terpenoids, coumarins, lactones, polyketides, and alkaloids, were isolated during this period. Furthermore, for the benefit of readers, the biosynthesis and potential medicinal value of these new compounds are also discussed in this review. Finally, the perspectives and directions for future research and the potential applications of the new compounds are summarized in various tables.
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KEYWORD
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Pestalotiopsis, Chemical constituents, Bioactivity, Biosynthesis
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